MCP For Claude Marketplace
UniProt

UniProt MCP Connector for Claude

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Search 250M+ protein sequences with functional annotations, gene names, subcellular locations, and amino acid data from the world's most comprehensive protein knowledge base.

3 tools Official Updated Oct 1, 2026 Official Vinkius Partner
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Connect your AI agent to UniProt — the Universal Protein Resource — the world's definitive knowledge base for protein sequence and functional information.

What you can do

  • Protein Search — Find proteins by name, gene symbol, function, or organism across 250M+ entries from both TrEMBL (auto-annotated) and Swiss-Prot (manually curated)
  • Accession Lookup — Get complete protein data by UniProt accession number (e.g., P04637 for human p53) including function, subcellular location, and full amino acid sequence
  • Gene Search — Find all proteins encoded by a specific gene name across multiple organisms to compare orthologs and paralogs

How it works

  1. Subscribe to this server
  2. Start searching proteins immediately — no API key required

Who is this for?

  • Molecular Biologists — quickly look up protein functions, domains, and post-translational modifications for experimental design
  • Bioinformaticians — retrieve protein sequences and annotations programmatically for large-scale comparative analyses
  • Drug Discovery Teams — identify therapeutic targets by searching protein functions and disease associations
protein-sequencesbioinformaticsgenomicsfunctional-annotationbiological-dataresearch-database

3 tools expose this connector's capabilities to your AI agent.

search_uniprot_gene

Returns all protein isoforms and their functional annotations. Find proteins encoded by a specific gene

get_uniprot_protein

Get full protein details by UniProt accession ID

search_uniprot

Returns protein name, gene, organism, function, subcellular location, and sequence. Try: insulin, hemoglobin, p53, BRCA1, spike protein. Search UniProt for proteins by name, function, or keyword

See how to talk to your AI agent using UniProt.

Tell me about the p53 tumor suppressor protein and its function.

P53_HUMAN (UniProt P04637): Gene TP53, Homo sapiens. 393 amino acids. Swiss-Prot reviewed ✅. Function: Acts as a tumor suppressor in many tumor types by inducing growth arrest or apoptosis. Activated in response to DNA damage, oncogene activation, and hypoxia. Located in nucleus and cytoplasm. Critical note: TP53 is the most frequently mutated gene in human cancers.

Find all proteins encoded by the BRCA1 gene.

Found 10 entries for gene BRCA1. Top result: BRCA1_HUMAN (P38398, Swiss-Prot reviewed ✅) — Homo sapiens, 1863 amino acids. Function: E3 ubiquitin ligase, key role in DNA repair via homologous recombination. Mutations associated with increased risk of breast and ovarian cancer. Also found orthologs in mouse (Q61187), rat, and zebrafish.

Look up UniProt accession Q9BYF1 and show me its full details.

Q9BYF1: ACE2_HUMAN — Angiotensin-converting enzyme 2. Gene: ACE2, Homo sapiens. 805 amino acids. Swiss-Prot reviewed ✅. Function: Metalloprotease that converts angiotensin II to angiotensin-(1-7). Notably serves as the functional receptor for SARS-CoV and SARS-CoV-2 spike proteins. Located in cell membrane.

Swiss-Prot contains 570K+ entries that have been manually reviewed and curated by expert biologists — the gold standard for protein annotation. TrEMBL contains 250M+ entries that are computationally annotated from gene sequences. Swiss-Prot entries are marked as 'reviewed' and are highly reliable; TrEMBL entries are automatically generated and may contain errors.

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