How is the Limit of Detection (LOD) calculated?

The LOD is calculated by multiplying the standard deviation of the blank measurements by the confidence multiplier and dividing the result by the calibration sensitivity.

Can I check if my baseline is stable?

Yes, you can use the `analyze_noise_profile` tool to evaluate the coefficient of variation and determine if your baseline is stable.

What inputs are needed for detection limit calculations?

You need to provide an array of blank signal measurements, the calibration sensitivity (slope), and a confidence multiplier.

Limit of Detection Calculator MCP Connector for Claude

A+

Calculate LOD, LOQ, and noise profiles using IUPAC-compliant statistical methods.

4 tools Official Updated Oct 1, 2026 Official Vinkius Partner

More Details Connect to Claude

This MCP server provides specialized analytical tools for determining the minimum detectable and quantifiable concentrations of substances. It uses IUPAC-compliant statistical methods to process blank measurements and calibration data. Use calculate_detection_limits to find the LOD and LOQ, analyze_noise_profile to assess baseline stability, validate_calibration_parameters to check statistical validity, and estimate_minimum_sample_size to plan your analytical runs.

analytical-chemistryiodpstatisticsdetection-limitslaboratory

Connect to Claude

Subscribe on Vinkius, then add this connector to Claude.ai or Claude Code.

① Claude.ai (web app)

Go to Settings → Connectors → Add custom connector
Paste the MCP endpoint URL below

https://edge.vinkius.com/vk_preview_oSJ2GBk2g3FdcQTvAZZuvZc5QxQONoQmHFGqfNHA/mcp

② Claude Code (terminal)

claude mcp add --transport http limit-of-detection-calculator https://edge.vinkius.com/vk_preview_oSJ2GBk2g3FdcQTvAZZuvZc5QxQONoQmHFGqfNHA/mcp

③ Claude Desktop

Add to claude_desktop_config.json:

{
  "mcpServers": {
    "limit-of-detection-calculator": {
      "url": "https://edge.vinkius.com/vk_preview_oSJ2GBk2g3FdcQTvAZZuvZc5QxQONoQmHFGqfNHA/mcp"
    }
  }
}

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