How do I design an affinity chromatography step?

You can use the `design_affinity_capture` tool by providing the target protein mass, resin binding capacity, ligand affinity strength, and impurity load.

Can I assess the entire purification process at once?

Yes, once you have completed individual designs for affinity, ion exchange, and size exclusion, you can use `evaluate_purification_protocol` to get a final feasibility score and summary.

What information is needed for ion exchange design?

To use `design_ion_exchange`, you need the protein's isoelectric point, the target buffer pH, the salt tolerance, and the target protein mass.

Chromatography Protein Purification Designer MCP Connector for Claude

A+

Design optimal chromatography parameters including column sizing, resin capacity, and elution strategies.

4 tools Official Updated Oct 1, 2026 Official Vinkius Partner

More Details Connect to Claude

This MCP server provides specialized tools for designing protein purification workflows. It allows users to calculate precise parameters for different separation modes. Use design_affinity_capture to determine column volume and elution strategies for affinity-based steps. Use design_ion_exchange to select resins and buffer conditions based on protein charge. Use design_size_exclusion to calculate column dimensions for polishing steps. Finally, use evaluate_purification_protocol to aggregate all design data into a complete feasibility assessment.

proteinchromatographypurificationbiochemistrylab-design

Connect to Claude

Subscribe on Vinkius, then add this connector to Claude.ai or Claude Code.

① Claude.ai (web app)

Go to Settings → Connectors → Add custom connector
Paste the MCP endpoint URL below

https://edge.vinkius.com/vk_preview_FyFhDAAiBcYEbUcTY2ln1dEDEqgVqLD1AqfAgDTr/mcp

② Claude Code (terminal)

claude mcp add --transport http chromatography-protein-purification-designer https://edge.vinkius.com/vk_preview_FyFhDAAiBcYEbUcTY2ln1dEDEqgVqLD1AqfAgDTr/mcp

③ Claude Desktop

Add to claude_desktop_config.json:

{
  "mcpServers": {
    "chromatography-protein-purification-designer": {
      "url": "https://edge.vinkius.com/vk_preview_FyFhDAAiBcYEbUcTY2ln1dEDEqgVqLD1AqfAgDTr/mcp"
    }
  }
}

Get full access on Vinkius

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