Chromatography Method Development

Chromatography Method Development MCP Connector for Claude

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Automate chromatography method selection, column recommendation, and resolution prediction.

4 tools Official Updated Oct 1, 2026 Official Vinkius Partner

This MCP server provides a specialized toolkit for automating chromatographic method development across HPLC, GC, and TLC modalities. It allows AI agents to perform complex chemical calculations including select_column for stationary phase selection, suggest_mobile_phase for solvent optimization, calculate_expected_resolution for predicting peak separation, and evaluate_method_feasibility to ensure compatibility with specific detectors.

hplcgctlcchromatographyanalytical-chemistry

4 tools expose this connector's capabilities to your AI agent.

suggest_mobile_phase

Determines the optimal composition of the mobile phase to achieve separation

select_column

Recommends the most suitable stationary phase based on analyte properties and the chosen chromatography modality

evaluate_method_feasibility

Assesses whether a proposed method is practical for a specific detection requirement

calculate_expected_resolution

Predicts the separation quality between two specific analytes in a given method

See how to talk to your AI agent using Chromatography Method Development.

Recommend a column for a non-polar analyte with a molecular weight of 250 Daltons using HPLC.

The recommended column for this non-polar analyte is a C18 bonded silica phase.

What is the optimal mobile phase for a C18 column in HPLC with a target polarity that is moderately polar?

The suggested mobile phase is an acetonitrile and water mixture with an organic ratio of 60%.

Will a UV-Vis detector work for an analyte with these properties?

Yes, the method is feasible for UV-Vis detection as the analyte contains suitable chromophores.

The server supports HPLC, GC, and TLC modalities.

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